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pericardial mesothelioma articles and products. Arm yourself with everything you need to know about pericardial mesothelioma
Pennsylvania Mesothelioma Lawyers
By nidiron damha
Mesothelioma is a type of cancer with too much disclosure to asbestos. Although the fact that they are fully conscious about the danger of mesothelioma extensive disclosure to asbestos, asbestos continues to threaten the workers. The survival of patients with peritoneal mesothelioma was night. However, the treatment for mesothelioma.The probability of successfully combating peritoneal mesothelioma depend on the stage of disease.
If one of your family members has the misfortune of mesothelioma caused to asbestos revelation, we recommend you consult with Pennsylvania mesothelioma lawyer.The pain and losses associated with this kind of disease can be expanded and a Pennsylvania specializing in litigation in which aggressive and help you recover damages that could be. Most Pennsylvania are able to provide info on earlier cases, as well as the number of procedures for treatment of mesothelioma, as the cases that be resolve quickly, and the amount of compensation received.
Pennsylvania specialized in the fight for the victims of cases of peritoneal mesothelioma. An expert and Pennsylvania can help, there are cases where there is a strong and a salary that is responsible for the company. For knowledge and understanding Pennsylvania helps fights for integrity and
Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in kashmir valley and influence of environmental factors.
In conclusion, GSTP1val/val and CYP2E1c1c2 genotypes/c2 allele increased the risk of ESCC and EADC, respectively, in the Kashmiri population; whereas GSTM3AB genotype imparted lower risk for both ESCC and EADC.
PMID: 20661821 [PubMed - in process] (Source: Nutrition and Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Evaluation of MTHFR677C>T Polymorphism in Prediction and Prognosis of Esophageal Squamous Cell Carcinoma: A Case-Control Study in a Northern Indian Population.
In conclusion, MTHFR677C>T polymorphism does not seem to have significant role either in susceptibility or survival of ESCC in a northern Indian population.
PMID: 20661822 [PubMed - in process] (Source: Nutrition and Cancer)
Correlation of the expression of human kallikrein-related peptidases 4 and 7 with the prognosis in oral squamous cell carcinoma
Very few articles have been written about the expression of kallikreins (KLK4 and KLK7) in oral cancers. Therefore, the purpose of this study was to examine and report on their prognostic potential.Eighty archival blocks of primary oral cancers were sectioned and stained for KLK4 and KLK7 by immunohistochemistry. The percentage and the intensity of malignant keratinocyte staining were correlated with patient survival using Cox regression analysis.Both kallikreins were expressed strongly in the majority of tumor cells in 68 of 80 cases: these were mostly moderately or poorly differentiated neoplasms. Staining was particularly intense at the infiltrating front. Patients with intense staining had significantly shorter overall survival (p < .05).This is the first observation on the patient sur...
Methylation-Specific Loop-Mediated Isothermal Amplification for Detecting Hypermethylated DNA in Simplex and Multiplex Formats [Molecular Diagnostics and Genetics]
CONCLUSIONS:
MS-LAMP provides a highly specific isothermal method for methylation detection and is well suited for multiplex approaches. (Source: Clinical Chemistry)
Skin Cancer or Mole?
How to Tell Harmless Moles and Birthmarks from Deadly Skin Cancers (Source: Health News: CBSNews.com)
Skin Cancer or Mole?
How to Tell Harmless Moles and Birthmarks from Deadly Skin Cancers (Source: Health News: CBSNews.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Skin Cancer or Mole?
How to Tell Harmless Moles and Birthmarks from Deadly Skin Cancers (Source: Health News: CBSNews.com)
A Single Arm Open Label Expanded Access Study of GDC-0449 in Patients with Locally Advanced or Metastatic Basal Cell Carcinoma
TCRS Clinical Trials, BASAL CELL CARCINOMA. TCRS is one of the leading centers for Phase I oncology trials in the nation. Clinical trials with agents directed at specific targets in patients' tumors were launched in November 2005. These clinical trials give options that did not exist before to Phoenix-area patients as well as patients from all over the country. TCRS is conducting clinical trials across a number of cancer types... (Source: TGen TCRS Clinical Trials)
Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signalling in melanocytes
In conclusion, L-PGDS may fine-tune the RA signalling in melanocytes. (Source: Journal of Biochemistry)
Monitoring of circulating tumor cells in a patient with synchronous metastatic melanoma and colon carcinoma
(Source: Annals of Oncology)
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study
Conclusion: Ipilimumab demonstrated clinical activity with encouraging long-term survival in a previously treated advanced melanoma population. (Source: Annals of Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Phase II trial of neoadjuvant temozolomide in resectable melanoma patients
Conclusions: The response proportion to TMZ in the neoadjuvant setting was 16%, not different than in the metastatic setting. Responses were seen even in tumors with a methylated MGMT promoter. Pretreatment cryopreserved tumor adequate for microarray analysis could be obtained in most, but not all, patients. Post-treatment tumor was unavailable in complete responders. (Source: Annals of Oncology)
Socially active environment can cause cancer tumors to shrink and even disappear
(NaturalNews) If you or someone you know ever receives a cancer diagnosis, especially one that is labeled "incurable" or fatal, take heart in the fact spontaneous regression (remission) has been reported in the medical literature numerous times for virtually all cancers. Spontaneous regression has been documented most often in neuroblastoma, renal cell carcinoma, lymphoma and malignant melanoma. And, as NaturalNews has previous reported, scientists have also discovered recently that some invasive breast cancers appear to simply go away on their own (http://www.naturalnews.com/024901.html). Now comes research from Ohio State University that could help explain what triggers spontaneous remissions.The new study, published in the July 9th issues of the journal Cell found that when mice with ca...
MMP-13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation
Conclusions:
Our data show for the first time that growth stimuli are mediated via MMP13 in melanocytes and melanoma, suggesting an autocrine MMP13-driven loop. Given that MMP13-specific inhibitors are already developed, our results support the evaluation of these inhibitors in the treatment of melanoma. (Source: Molecular Cancer)
Transcriptome analysis of human cancer reveals a functional role of Heme Oxygenase-1 in tumor cell adhesion
Conclusions:
Collectively, our results show that HO-1 expression determines a distinct 'molecular signature' in cancer cells, which is enriched in genes associated with tumorigenesis. The protein network downstream of HO-1 modulates adhesion, signaling, transport, and other critical cellular functions of neoplastic cells and thus promotes tumor cell growth and dissemination. (Source: Molecular Cancer)
Postoperative Radiotherapy Improved Survival of Poor Prognostic Squamous Cell Carcinoma Esophagus [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions
Postoperative radiotherapy is indicated for patients with poor disease-related prognostic factors. (Source: The Annals of Thoracic Surgery)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Desmoplastic Malignant Melanoma Presenting as Large Lung Mass [CASE REPORTS]
We describe a case of successful minimally invasive thoracoscopic surgical resection of metastatic desmoplastic malignant melanoma replacing the entire right lower lobe of the lung, presenting 4 years after the initial complete resection of the primary scalp lesion. An 89-year-old man presented with a 6-month history of right-sided chest pain. A computed tomographic scan showed a large paravertebral mass with possibility of chest wall invasion. Core biopsy initially raised the suspicion of a schwannoma. We also discussed the atypical delayed presentation and misleading radiologic and histologic findings. (Source: The Annals of Thoracic Surgery)
Canadian Researchers Testing Unique Vaccines For Prion Diseases And Common Cancers
Several Canadian researchers have come together to help control the relentless spread of a prion disease, chronic wasting disease (CWD) in deer and elk, through vaccines. At the same time they aim to generate safe and effective therapies for common cancers. This simultaneous research is possible thanks to a unique connection they have discovered between the two unrelated diseases. The project builds on links between prion proteins present in certain prion diseases like CWD in animals and common cancers in people like melanoma and lymphoma... (Source: Health News from Medical News Today)
Semaphorin 3E, an exception to the rule
Class 3 semaphorins (Sema3s) regulate axon guidance, angiogenesis, tumor growth, and tumor metastasis. Neuropilins (NRPs; NRP1 and NRP2) are the cell surface receptors for the Sema3s. However, to signal, interaction of Sema3s and NRPs with plexins is obligatory. In this issue of the JCI, Casazza and colleagues report data that challenge the conventional wisdom about the role of Sema3s in tumor metastasis. As a rule, Sema3B and Sema3F, for example, are inhibitors of tumor angiogenesis, progression, and metastasis. However, Casazza et al. found that Sema3E inhibited tumor growth but atypically promoted invasiveness and metastasis. This metastatic potential was dependent on Plexin D1 expression but was independent of NRP expression. Of clinical importance, Sema3E and Plexin D1 were found to b...
Multiple keratocystic odontogenic tumors associated with nevoid basal cell carcinoma syndrome having distinct PTCH1 mutations: a case report
Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder characterized by developmental abnormalities and a predisposition to cancers. Although multiple jaw tumors, such as keratocystic odontogenic tumors (KCOTs), are one of the most frequent complications in NBCCS, the molecular mechanism for how KCOTs develop in NBCCS is poorly understood. A 15-year-old girl with 2 jaw tumors was diagnosed as NBCCS according to the clinical criteria. The pathologic findings indicated that the 2 tumors were consistent with KCOTs. A PTCH1 mutation, c.1472delT, was detected in her peripheral blood as well as in the 2 tumors. Interestingly, an additional PTCH1 mutation, c.264_265insAATA, that was not present in the peripheral blood, was found in the maxillary tumor but not the mandi...
Specific oncogene plays a role in lung squamous cell carcinoma
(Public Library of Science) The identification of an oncogene specific to lung squamous cell carcinoma suggests that genetic activation of this oncogene could be used as an identification marker for this type of lung cancer. (Source: EurekAlert! - Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Invasive pattern grading score designed as an independent prognostic indicator in oral squamous cell carcinoma
Conclusions: Our study confirms the validity of the IPGS, an indicator that is simple and easy to use. IPGS not only provides histological assessment of biological behaviour, but also offers an independent prognostic factor that may influence the treatment of OSCC. (Source: Histopathology)
Lymphedema beyond breast cancer
Secondary lymphedema is a debilitating, chronic, progressive condition that commonly occurs after the treatment of breast cancer. The purpose of the current study was to perform a systematic review and meta-analysis of the oncology-related literature excluding breast cancer to derive estimates of lymphedema incidence and to identify potential risk factors among various malignancies.The authors systematically reviewed 3 major medical indices (MEDLINE, Cochrane Library databases, and Scopus) to identify studies (1972-2008) that included a prospective assessment of lymphedema after cancer treatment. Studies were categorized according to malignancy, and data included treatment, complications, lymphedema measurement criteria, lymphedema incidence, and follow-up interval. A quality assessment of...
NICE guideline on the management of metastatic malignant disease of unknown primary origin
Source: NICE
Area: Evidence > Guidelines
The National Institute for Health and Clinical Excellence (NICE) has issued clinical guidelines for the management of metastatic malignant disease of unknown primary origin. The advice in the guideline covers:
. the treatment and care of adults with suspected or diagnosed cancer of unknown primary, including people who have been treated for cancer before.
In this guideline 'cancer of unknown primary' refers to a particular type of cancer, called carcinoma.
It does not look at:
. children (under 18) with cancer of unknown primary
. adults with metastatic cancer with a known site of primary origin
. adults with cancer that is not carcinoma (for example lymphoma, melanoma, sarcoma). (Source: NeLM - Gu...
Mandibular cuniculatum carcinoma: Apropos of 3 cases and literature review
Cuniculatum carcinoma is a well-differentiated form of squamous cell carcinoma that shares histologic characteristics with papillary squamous cell carcinoma and verrucous carcinoma. Cuniculatum carcinoma usually occurs on the plantar region, and only 16 cases involving the oral cavity have been described in the literature.The authors have reported 3 cases of mandibular cuniculatum carcinoma. All of the patients were in a great deal of pain. Histologic diagnosis was difficult due to the presence of few cellular atypies. Clinical criteria, osseous lysis, and the coexistence of multiple intraosseous well-differentiated, hyperkeratotic papillomatous lesions with few cellular atypies sign the diagnosis.No local recurrence has been reported after treatment with radical surgery alone.The diagnosi...
Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma
William Lockwood and colleagues show that the focal amplification of a gene, BRF2, on Chromosome 8p12 plays a key role in squamous cell carcinoma of the lung. (Source: PLoS Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
To Ward Off Lizardlike Skin, Bring Along Portable Shade
If you're going out today, bring your umbrella. This tip comes from the Skin Cancer Institute at the Arizona Cancer Center for a way to prevent skin cancer ? use your umbrella as a parasol.
(Source: Health)
Skin cancers in renal transplant recipients: A description of the renal transplant cohort in Bern.
CONCLUSION: Skin cancers are increased in the renal transplant population. Main risk factors for skin cancers are fair skin type and long duration of immunosuppressive therapy. A follow-up programme is necessary for early detection of skin cancer and precancerous conditions. Preventive strategies should include specialist dermatological monitoring and self-examination.
PMID: 20652847 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Successful Treatment of Esophageal Squamous Cell Carcinoma in a Patient with Fanconi Anemia
We report here a patient first diagnosed with Fanconi anemia at age 10. Bone marrow transplantation was performed at age 23 and repeated after an episode of rejection at age 25. Hematologic findings returned to normal, but chronic graft-versus-host disease persisted. Esophageal cancer developed at age 35. Invasion of the bronchus and aorta by the tumor was suspected on computed tomography. Chemoradiotherapy was administered to down-stage the tumor, using low-dose cisplatin and 5-fluorouracil. After two courses of chemotherapy with cisplatin (total dose, 100 mg) and 5-fluorouracil (5000 mg) plus radiotherapy (30 Gy), Grade 3 diarrhea and bone marrow suppression developed, and treatment was discontinued. After resolution of toxicity, a good response to the neoadjuvant therapy was seen on com...
Sunscreen Concerns Unfounded, Experts Say
Cancer reports questionable; skin protection essential, they note
Source: HealthDay
Related MedlinePlus Pages: Skin Cancer, Sun Exposure (Source: MedlinePlus Health News)
Key Enzyme Repairs Sun-Damaged DNA
Researchers have long known that humans lack a key enzyme -- one possessed by most of the animal kingdom and even plants -- that reverses severe sun damage. For the first time, researchers have witnessed how this enzyme works at the atomic level to repair sun-damaged DNA. The discovery holds promise for future sunburn remedies and skin cancer prevention... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
How key enzyme repairs sun-damaged DNA
Researchers have long known that humans lack a key enzyme -- one possessed by most of the animal kingdom and even plants -- that reverses severe sun damage. For the first time, researchers have witnessed how this enzyme works at the atomic level to repair sun-damaged DNA. The discovery holds promise for future sunburn remedies and skin cancer prevention. (Source: ScienceDaily Headlines)
Linear basal cell carcinoma: a distinct condition?
Linear basal cell carcinoma (BCC) was first reported as a distinct condition in 1985. Having managed two cases recently, we reviewed the published literature on this condition. The aim of the study was to review all reported cases in the literature and summarize the demographic data, histological and clinical features, and treatment methods used. We conducted a literature search from 1985 to 2008 for all published articles on linear BCC [PubMed (National Library of Medicine, Bethesda, MD, USA)] using the keywords 'linear' and 'basal cell carcinoma'. In total, 37 cases of linear BCC in 15 papers were reviewed. There was an equal male : female ratio in the cases. The periocular skin and the neck were the sites most frequently involved. Although the nodular pattern was the commonest histologi...
Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies
In the combined antiretroviral therapy (cART) era, non-acquired immunodeficiency syndrome (AIDS)-defining malignancies account for more morbidity and mortality in human immunodeficiency virus-infected patients than AIDS-defining malignancies. However, conflicting data have been reported on the relationship between immunodeficiency and the development of some non-AIDS-defining malignancies.A total of 14,453 patients from the prospective, multinational EuroSIDA cohort were included. Malignancies were classified as virus-related, non-virus-related epithelial, and other. The incidence of non-AIDS-defining malignancies was calculated stratified by current CD4 count. Poisson regression was used to investigate factors associated with the development of non-AIDS-defining malignancies.A total of 35...
Tumor-initiating activity and tumor morphology of HNSCC is modulated by interactions between clonal variants within the tumor
Authors: Sarina R Cameron, Alison L Dahler, Liliana B Endo-Munoz, Ibtissam Jabbar, Gethin P Thomas, Paul J Leo, Kim Poth, Danny Rickwood, Alexander Guminski
& Nicholas A Saunders (Source: Laboratory Investigation AOP)
Subatomic sunscreen: How light particles can repair UV-damaged DNA
The life-giving sun can be quite rough on genetic material. Most organisms, including plants and many animals, are equipped with a special enzyme in their cells that is quick to repair DNA damage wrought by the sun's ultraviolet (UV) rays . Humans, however, have less effective repair strategies and as a result are prone to painful sunburns and deadly skin cancer . [More] (Source: Scientific American - Official RSS Feed)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Researchers discover how key enzyme repairs sun-damaged DNA
(Ohio State University) Researchers have long known that humans lack a key enzyme -- one possessed by most of the animal kingdom and even plants -- that reverses severe sun damage. For the first time, researchers have witnessed how this enzyme works at the atomic level to repair sun-damaged DNA. The discovery holds promise for future sunburn remedies and skin cancer prevention. (Source: EurekAlert! - Medicine and Health)
Solarium use in Australia, recent trends and context.
Conclusions and implications: Although solarium use in Australia is relatively low, it is highest among young adult women. These data show encouraging downward trends in use, and provide a foundation for monitoring the impact of forthcoming regulatory changes to the solarium industry.
PMID: 20649786 [PubMed - in process] (Source: Australian and New Zealand Journal of Public Health)
Cbfa1/Runx2 expression in an ossifying basal cell carcinoma of the eyelid
Abstract A case of basal cell carcinoma (BCC) with intratumoural bone formation affecting the eyelid of a 77-year-old lady is described.
Bone formation in BCCs is an uncommon event. We revised the 23 cases described in the literature: most of them occurred on
the face. The pathophysiological mechanism responsible for ossification in cutaneous lesions remains unclear. The bone often
develops adjacent to, or within hair follicles. We evaluated the immunohistochemical expression in the present case of Cbfa1/Runx2, an early marker for osteoblastic progenitor cells. A well-developed lamellar bone with adipose bone marrow was observed
both in the superficial stroma and intratumourally. Cbfa1/Runx2 was localised in the osteocytes of the heterotopic bone and
in the keratin cysts of...
Pill for skin cancer developed that could shrink tumours by up to 50%
Scientists believe the pill - which could be available within three years - will greatly improve the length and quality of life for those with malignant melanoma, the deadliest form of skin cancer. (Source: the Mail online | Health)
Merkel cell polyomavirus in naevoid basal cell carcinoma syndrome-associated basal cell carcinomas and sporadic trichoblastomas
Merkel cell carcinoma (MCC) is a very aggressive neuroendocrine non-melanoma skin cancer (NMSC) of elderly or immunosuppressed individuals . Approximately 80% of MCC harbor the recently detected Merkel cell polyomavirus (MCPyV) within the tumor DNA . MCPyV-positive MCC reveal tumor specific truncating mutations within the large T antigen (LTAg) of MCPyV which are not found in the MCPyV wildtype . Thus epidemiology, clonal integration and tumor specific mutations within the LTAg of MCPyV are strongly supporting an important role of MCPyV in the etiopathogenesis of human MCC. However, the presence of MCPyV has been reported in NMSC of immunosuppressed and immunocompetent patients, including squamous cell carcinomas (SCC), Bowen's disease (BD) and basal cell carcinoma (BCC) . BCCs are among t...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Cinnamon extract induces tumor cell death through inhibition of NFkB and AP1
Conclusion:
Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFB and AP1 activities and their target genes in vitro and in vivo mouse melanoma model. Hence, further elucidation of active components of cinnamon extract could lead to development of potent anti-tumor agent or complementary and alternative medicine for the treatment of diverse cancers. (Source: BMC Cancer)
Letter: Skin cancer in albinos at the University of Calabar Teaching Hospital, Calabar, Nigeria.
Authors: Asuquo ME, Otei OO, Omotoso J, Bassey EE
We evaluated all the albinos with a histologic diagnosis of skin cancer seen in the University of Calabar Teaching Hospital, Calabar, Nigeria, during the 7-year period, (January 2001 to December 2007). The ages, sex, clinical presentation/site(s), number of lesions per patient, type of skin cancer, treatment, outcome and follow up were analyzed. This was compared with the total number of skin cancers. Of the skin cancers diagnosed, 11 percent were in patients with albinism.
PMID: 20409421 [PubMed - indexed for MEDLINE] (Source: Dermatol Online J)
Relationships of cervical lymph node metastasis to histopathological malignancy grade, tumor angiogenesis, and lymphatic invasion in tongue cancer
Abstract Cervical lymph node (CLN) metastasis from oral cancer correlates with poor prognosis. Therefore, accurate assessment of CLN
status is crucial in treatment planning. However, there are few reports focusing on CLN metastasis from tongue cancer. Further,
the growth and progress of the tumor are known to be profoundly related to histological malignancy, tumor angiogenesis, and
lymphangiogenesis. Thus, this study aimed to identify predictive factors for CLN metastasis in tongue squamous cell carcinoma
(SCC). Initial biopsy specimens obtained from 30 patients with tongue SCC were examined to evaluate histological malignancy
according to Anneroth?s classification. In addition, blood vessel density, lymph vessel density, and lymphatic invasion in
the tumor were evaluate...
64-row MDCT perfusion of head and neck squamous cell carcinoma: technical feasibility and quantitative analysis of perfusion parameters
Conclusion 64-row CT quantitative perfusion imaging allows head and neck SCC to be distinguished from normal tissues.
Content Type Journal ArticleCategory Head and NeckDOI 10.1007/s00330-010-1898-0Authors
Lorenzo Faggioni, University of Pisa Diagnostic and Interventional Radiology Via Paradisa 2 ? 56100 Pisa ItalyEmanuele Neri, University of Pisa Diagnostic and Interventional Radiology Via Paradisa 2 ? 56100 Pisa ItalyFrancesca Cerri, University of Pisa Diagnostic and Interventional Radiology Via Paradisa 2 ? 56100 Pisa ItalyEugenia Picano, University of Pisa Diagnostic and Interventional Radiology Via Paradisa 2 ? 56100 Pisa ItalyVeronica Seccia, University of Pisa Division of Otorhinolaryngology Via Paradisa 2 ? 56100 Pisa ItalyLuca Muscatello, University of...
18F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with 18F-FDG PET and immunohistochemistry
Conclusions Uptake of FAMT correlated with cellular proliferation of OSCC. FAMT-PET may be a useful procedure to evaluate tumor proliferation
of OSCC.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-010-0398-2Authors
Go Miyashita, Gunma University Graduate School of Medicine Department of Stomatology and Oral Surgery Maebashi JapanTetsuya Higuchi, Gunma University Graduate School of Medicine Department of Diagnostic Radiology and Nuclear Medicine 3-39-22 Showa-machi Maebashi Gunma 371-8511 JapanNoboru Oriuchi, Gunma University Graduate School of Medicine Department of Diagnostic Radiology and Nuclear Medicine 3-39-22 Showa-machi Maebashi Gunma 371-8511 JapanYukiko Arisaka, Gunma University Graduate School of Medicine Department of Diagnostic R...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Squamous cell carcinoma arising in a median sternotomy scar?a case report and a brief review of literature
Abstract A 71 year old gentleman presented with a nodular growth in the upper end of a median sternotomy scar 17 years after an uneventful
cardiac surgery. In the months immediately following the surgery he had itching over the scar and there was an episode of
superficial infection in the scar two years hence. He presented this time with a history of itching, ulceration and nodule
formation in the upper end of the old surgical scar over the last five months. On examination there was an ulcer at the top
end of the sternotomy scar containing a three centimetre diameter nodular growth. He underwent a wide excision biopsy of the
lesion which was reported as squamous cell carcinoma. Carcinomas are known to arise from scars of diverse aetiologies, but
to our knowledge ...
Melanoma increasing among Hispanic men, black women in Florida
Rouhani P. Arch Dermatol. 2010;146:741-746. (Source: HemOncToday.com)
Nimotuzumab with chemoradiation confers survival advantage in treatment naïve head and neck tumors overexpressing EGFR.
Authors: Basavaraj C, Sierra P, Shivu J, Melarkode R, Montero E, Nair P
Head and neck cancer mainly associated with chewing of betel preparations including tobacco is common to South East Asia. Ninety two treatment naïve patients from India with squamous cell carcinoma in advanced stage received an anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody (Nimotuzumab) in addition to standard therapy, compared to the latter alone. In this Phase IIb study, the tissue expression of ErbB family proteins and downstream molecules from pre-treatment samples was evaluated. Their association with clinical response and survival was investigated. Marker expression in tumor adjacent sections was evaluated by immunohistochemistry. The association of the molecular expression and intensity...
Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma
Conclusion : These findings indicate that mast cells may play a role in up regulation of tumor angiogenesis in OSCC probably through mast cell tryptase. (Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3))
Malignant melanoma of the mandibular gingiva: A rare occurrence
BVR Reddy, GR Sridhar, CH Anuradha, P Chandrasekhar, KP LingamaneniIndian Journal of Dental Research 2010 21(2):302-305Primary mucosal malignant melanoma of the oral cavity is a rare tumor. It accounts for only 0.2-8% of all malignant melanomas. This malignancy commonly affects male subjects and is more frequently seen on the hard palate and maxillary gingiva. The peak age for diagnosis of oral melanoma is between 55 and 65 years. A biopsy is required to establish a diagnosis. Ablative surgery with tumor-free margins remains the treatment of choice. It has a much poorer prognosis than its counterpart on the skin. Here, we present a case of malignant melanoma of the mandibular lingual gingiva in a 55-year-old male patient. Immunohistochemistry and special stains were conducted for co...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Increased rates of melanoma in non-White people observed in Florida
Rates of melanoma among Black and Hispanic people living in Florida differ from those among people of similar ethnicity living in different US states, say researchers who suggest that the generally higher rates may be due to the high UV index in Florida. (Source: MedWire News - Dermatology)
Surgical salvage of the oropharynx after failure of organ-sparing therapy
The purpose of this study was to evaluate the efficacy of salvage surgery for local recurrences of oropharyngeal squamous cell carcinoma (OPSCC) and identify predictors of survival.The authors reviewed 264 patients with OPSCC treated with radiation or chemoradiation identified retrospectively. Of the 77 patients that experienced recurrences, 37 had local or local and regional recurrences and were considered for salvage surgery.Of the 37 patients with local or local and regional recurrence, 5 had unresectable disease whereas 3 refused surgery. The remainder underwent salvage surgery with 2-year and 5-year survival rates of 64.5% and 43.4%, respectively. A history of alcohol abuse and positive surgical margins were the only predictors of poorer overall survival (p < .05) after salvage surger...
Unusual Misdiagnosis of Choroidal Melanoma
Ophthalmologica 1983;186:219–222 (DOI:10.1159/000309289) (Source: Ophthalmologica)
Autochthonous primary and metastatic melanomas in Hgf-Cdk4(R24C) mice evade T cell-mediated immune surveillance.
Authors: Landsberg J, Gaffal E, Cron M, Kohlmeyer J, Renn M, Tüting T
Summary Genetically engineered mouse models offer new opportunities to investigate the role of cell-mediated immunity in the natural progression of melanoma in an immunocompetent host. Here we report that Hgf-Cdk4(R24C) mice spontaneously develop a spectrum of primary melanomas with high penetrance during their first year of life. Malignant transformation proceeds in a stepwise manner from multiple melanocytic nevi to single nodular melanomas and disseminated metastases in most mice. Migrating melanoma cells invade the draining lymph nodes without activating the immune system. Autochthonous primary tumors are destroyed following experimental introduction of immune surveillance using an adoptive lymphocyte transfer...
The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand.
Authors: Yang NY, Lopez-Bergami P, Goydos JS, Yip D, Walker AM, Pasquale EB, Ethell I
PMID: 20649938 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Selective regional perfusion of the bilateral external carotid arteries with pegylated liposomal doxorubicin and melphalan to treat metastatic malignant melanoma of the scalp
We present the case of a 79-year-old patient with extensive metastatic malignant melanoma (MM) of the scalp. Cutaneous MM of the head and neck often presents a therapeutic challenge. Radical surgical procedures and conventional chemotherapy are often unfeasible and contraindicated because of the difficult anatomy, the extent of the tumour process, and systemic toxicity. In our patient, selective intra-arterial perfusion with pegylated liposomal doxorubicin (PLD) and melphalan was performed after catheterization of both bilateral external carotid arteries with an arterial port system. PLD 4.5 mg/m2 and melphalan (1.35 mg/m2, followed by 2.7 mg/m2 after reaching tolerance) were given as short-term infusions at two-weekly intervals into the right and left external carotid arteries, respective...
Melanoma: early diagnosis using in vivo reflectance confocal microscopy
(Source: Clinical And Experimental Dermatology)
1-Deoxynojirimycin Inhibits Metastasis of B16F10 Melanoma Cells by Attenuating the Activity and Expression of Matrix Metalloproteinases-2 and -9 and Altering Cell Surface Glycosylation
Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)
Differentiating Normal and Basal Cell Carcinoma Human Skin Tissues In Vitro Using Dispersive Raman Spectroscopy: A Comparison Between Principal Components Analysis and Simplified Biochemical Models
Photomedicine and Laser Surgery , Vol. 0, No. 0. (Source: Photomedicine and Laser Surgery)
The Postradiation Neck: Evaluating Response to Treatment and Recognizing Complications
CONCLUSION. Radiation therapy results in imaging findings of tissue
edema followed by fibrosis, scarring, and atrophy. Complications from
radiation therapy can occur months to years after treatment. Findings of a new
mass, lymphadenopathy, or bone or cartilage destruction must be viewed as
concerning for recurrent disease. (Source: American Journal of Roentgenology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Basal Cell Carcinoma and the Carcinogenic Role of Aberrant Hedgehog Signaling
Recent progress in understanding Hh-dependent BCC tumorigenesis is summarized. Future Oncology (Source: Medscape Today Headlines)
Onyx Pharmaceuticals Initiates A Phase 3 Carfilzomib Combination Trial In Relapsed Multiple Myeloma
Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) announced that the company has begun enrollment in the ASPIRE trial, a Phase 3 international clinical trial evaluating carfilzomib in combination with lenalidomide (Revlimid®) and low dose dexamethasone in patients with relapsed multiple myeloma. The company has an agreement with the U.S. Food and Drug Administration (FDA) on a Special Protocol Assessment (SPA) and received Scientific Advice from the European Medicines Agency (EMA) on the design and planned analysis of the ASPIRE trial... (Source: Health News from Medical News Today)
Archer Biosciences Announces Initiation Of Dosing In 3rd Cohort In Metastatic Melanoma Clinical Trial
Archer Biosciences, Inc. announced that the trial of its novel, proprietary drug TPI-287 (an abeotaxane) for the treatment of metastatic melanoma has initiated a third drug-escalation cohort. The primary objective of this study is to determine the safety, tolerability and maximum tolerated dose (MTD) of TPI-287 in combination with temozolomide (TMZ) in adult patients with metastatic melanoma... (Source: Health News from Medical News Today)
Florida's Minorities See Unusual Melanoma Patterns
Title: Florida's Minorities See Unusual Melanoma PatternsCategory: Health NewsCreated: 7/21/2010 12:10:00 PMLast Editorial Review: 7/22/2010 (Source: MedicineNet Cancer General)
Florida's Minorities See Unusual Melanoma Patterns
Title: Florida's Minorities See Unusual Melanoma PatternsCategory: Health NewsCreated: 7/21/2010 12:10:00 PMLast Editorial Review: 7/22/2010 (Source: MedicineNet Skin General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Florida's Minorities See Unusual Melanoma Patterns
Statewide skin cancer rates for blacks, Hispanics differ from U.S. trends (Source: Cancercompass News: Other Cancer)
Objective melanoma progression
Many aspects of the natural history of malignant melanoma (MM) are still unclear, specifically its appearance at onset and particularly how it changes in time. The purpose of our study was to retrospectively determine objective changes in melanoma over a 3[ndash]24-month observation period. Our study was carried out in two Italian dermatology centers. Digital dermoscopy analyzers (DB-Mips System) were used to retrospectively evaluate dermoscopic images of 59 MM (with no initial clinical aspects suggesting melanoma) under observation for 3[ndash]24 months. The analyzer evaluates 49 parameters grouped into four categories: geometries, colors, textures and islands of color. Multivariate analysis of variance for repeated measures was used to evaluate the statistical significance of the changes...
Multimodal imaging to study the morphochemistry of basal cell carcinoma
Basal cell carcinoma is the most abundant malignant neoplasm in humans, the pathology of which is characterized by an abnormal proliferation of basal cells. Basal cell carcinoma can show a variety of different morphologies, which are based on different cellular biology. Furthermore, the carcinoma often grows invisibly to the eye imbedded in the surrounding skin. Therefore, in some cases its clinical detection is challenging. Thus, our work aims at establishing an unsupervised tissue classification method based on multimodal imaging and the application of chemometrics to discriminate basal cell carcinoma from non-diseased tissue. A case study applying multimodal imaging to ex-vivo sections of basal cell carcinoma is presented. In doing so, we apply a combination of various linear and non-li...
Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma
Recurrent head and neck squamous cell carcinoma (HNSCC) remains a difficult cancer to treat. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents, cetuximab, and AMG-479 (monoclonal antibody against insulin-like growth factor-1 receptor [IGF-1R]).The clinical information was collected by a retrospective medical record review under an Institutional Review Board-approved protocol. From 4 tumors and 2 normal mucosal epithelia, global gene expression, and IGF-1R and dihydrofolate reductase (DHFR) protein levels were determined.Effective target inhibition in the tumor was confirmed by the decreased protein levels of total and phospho-IGF-1R after treatment with AMG-479. Decreased level of DHFR and conversion of a g...
Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus
Human papillomavirus (HPV)-positive cases of squamous cell carcinoma of the head and neck (SCCHN) have a much better disease outcome compared to SCCHN cases lacking HPV. Differences in microRNA (miRNA) expression may affect their clinical outcomes.The miRNA expression was studied using microarrays and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in HPV-16-positive and HPV-negative SCCHN cell lines. The role of HPV-16 E6 and E7 oncogenes in altering miRNA expression was investigated using human foreskin keratinocytes (HFKs).The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratin...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Combined therapy for thyroid squamous cell carcinoma
Squamous carcinoma of the thyroid is a rare aggressive disease, resulting in poor prognosis.We combined cisplatin with paclitaxel on a weekly basis as induction therapy, achieving a high cumulative dose, in a patient with squamous cell tumor of the thyroid with arterial encasement. After surgery, pathologic examination confirmed a complete resection of the primary tumor with clear margins, revealing a successful induction treatment with chemotherapy.Our patient now has a recurrence-free survival of >20 months, longer than the mean survival described in the literature. © 2010 Wiley Periodicals, Inc. Head Neck, 2010 (Source: Head and Neck)
Insulin-like growth factor II mRNA-binding protein 3: A novel prognostic biomarker for oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3 can be used as a prognostic biomarker for OSCC.We performed immunohistochemistry and Western blotting to examine IMP3 expression in human tissues. We also investigated correlations among IMP3 expression, clinicopathologic factors, and overall survival.IMP3 was overexpressed in OSCC cells. The expression was correlated with high histologic grade, lymph node metastasis, and advanced tumor and clinical stages. Univariate analysis indicated that advanced clinical stages, lymph node metastases, and IMP3 expression were predicti...
Enhanced local dendritic cell activity and tumor-specific immunoresponse in combined radiofrequency ablation and interleukin-2 for the treatment of human head and neck cancer in a murine orthotopic model
Radiofrequency ablation (RFA) is a minimally invasive tumor destruction technique and can provide the antigen source initiating tumor immunity. However, induced immune response is weak and requires additional immunotherapy for optimized RFA treatment against cancer.A murine orthotopic model of head and neck squamous cell carcinoma (HNSCC) was established to investigate the efficacy and mechanism of an RFA + interleukin-2 (IL-2) combination adenoviral gene therapy among 6 groups. Tumor volume change, apoptosis, in situ macrophage recruitment, cytotoxic T lymphocyte (CTL) activity, migration of dendritic cells into the regional lymph nodes, and systemic antitumor immunity were examined.RFA + IL-2 therapy induced the highest levels of macrophage recruitment and dendritic cell migration result...
Central compartment dissection in laryngeal cancer
We report here a review of the literature intended to clarify the nomenclature and boundaries of the nodes in the "central compartment" of the neck, the frequency with which tumors from the different laryngeal sites metastasize to these nodes, and the indications for central compartment node dissection in the treatment of cancers of the larynx. From this review, we conclude that, until consensus is reached about grouping of the lymph nodes in this area, it is best to refer to these nodes by their anatomic location, ie, prelaryngeal, pretracheal, or paratracheal lymph nodes. It is also advisable to describe dissection of these nodes as selective neck dissection (SND) with an annotation about the specific lymph node groups removed. Metastases in prelaryngeal and paratracheal lymph nodes in p...
Contrast-enhanced 18F-FDG-PET/CT for the assessment of necrotic lymph node metastases
Cystic lymph node metastasis (CLNM) is commonly found in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (SCC). The aim of this study was to compare the accuracy in detecting cystic lymph node metastasis from tonsillar SCC between contrast-enhanced CT, 18F- fluorodeoxyglucose-positron emission tomography (FDG-PET), non-enhanced 18F-FDG-PET/CT, and contrast-enhanced 18F-FDG-PET/CT.Thirty-four patients with a tonsillar SCC undergoing a pretreatment contrast-enhanced 18F-FDG-PET/CT followed by a neck dissection as a standard of reference were included. The contrast-enhanced CT part, the 18F-FDG-PET part, the non-enhanced 18F-FDG-PET/CT part, and the contrast-enhanced 18F-FDG-PET/CT were assessed separately for correct N classification and the differentiation of N0 vers...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Invivo modulation of angiogenesis by beta 2 glycoprotein I.
Authors: Passam FH, Qi JC, Tanaka K, Matthaei KI, Krilis SA
Beta 2 glycoprotein I (beta2GPI) is the major auto antigen in the antiphospholipid syndrome but also interacts with fibrinolytic and angiogenic proteins. The aim of this study was to examine the angiogenic potential of beta2GPI in vivo in beta2GPI deficient mice utilizing angiogenic assays. beta2GPI deficient mice show increased microvessel formation in comparison to beta2GPI replete controls when injected with growth factor free-matrigel implants. However, microvessel formation in matrigel plugs of beta2GPI deficient mice was less than in beta2GPI replete mice when basic fibroblast growth factor (bFGF) was included in the matrigel. Hemoglobin content was higher in vascular endothelial growth factor (VEGF) containing-matrigel ...
Expression of a chemokine BRAK/CXCL14 in oral floor carcinoma cells reduces the settlement rate of the cells and suppresses their proliferation in vivo.
We reported previously that the forced expression of the chemokine BRAK/CXCL14 in head and neck squamous cell carcinoma cells decreased the rate of tumor formation and size of tumor xenografts in athymic nude mice and SCID mice. In order to clarify the expression of BRAK/CXCL14 affected either the settlement of carcinoma cells in host tissues in vivo or proliferation of the colonized carcinoma cells or both, we prepared oral floor carcinoma-derived HSC-2 cells in which BRAK/CXCL14 expression was induced upon doxycycline treatment. Then 30 nude mice were separated into 3 groups composed of 10 mice per group: Group I, the control, in which the engineered cells were directly xenografted onto the back of the mice; Group II, the cells were xenografted and then the mice were treated with doxycyc...
Darker Skin Doesn't Mean Melanoma Immunity
Melanoma is on the rise among certain groups of dark-skinned Floridians, new research shows. Reuters Health Information (Source: Medscape Medical News Headlines)
Darker skin doesn't mean melanoma immunity
NEW YORK (Reuters Health) - Melanoma is on the rise among certain groups of dark-skinned Floridians, new research shows. (Source: Reuters: Health)
Controlling Skin Cancer in Renal Transplant Patients
Can conversion to sirolimus immunosuppression reduce the recurrence of skin cancer in renal transplant patients? Dr. Ron Shapiro discusses a randomized, controlled study that shows promising results. Medscape Transplantation (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Warning: Beach Umbrellas Do Not Block Out All Solar Radiation
A team of researchers from the University of Valencia (UV) has proven that 34% of ultraviolet radiation filters through under beach umbrellas. According to what is published in the journal Photochemistry and Photobiology, umbrellas intercept the full direct flow that comes from the Sun, but not the diffused radiation that penetrates through from the sides... (Source: Health News from Medical News Today)
Of patches, blotches, speckles and stripes.
Authors: Arnheiter H
PMID: 20636990 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Vincent J. Hearing, PhD.
Authors: Pawelek J
PMID: 20636991 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Evaluation of MTHFR677C>T Polymorphism in Prediction and Prognosis of Esophageal Squamous Cell Carcinoma: A Case-Control Study in a Northern Indian Population
(Source: Nutrition and Cancer)
Medically reported work-related ill-health in the UK agricultural sector
Conclusions These medically reported incidence data provide information on WRI in the UK agricultural sector. Consistent with other sources, there are increased risks for asthma, allergic alveolitis and MSD and a reduced risk for mental ill-health. The raised incidence of skin cancer requires confirmation and further comparison with reliable estimates of the incidence in the UK workforce. (Source: Occupational Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Florida's Minorities See Unusual Melanoma Patterns
Melanoma trends among minority groups in Florida, the Sunshine State, are different than national trends, a new study finds. Researchers evaluated data on more than 36,000 melanoma patients in the Florida Cancer Data System and over 73,000 patients in the national Surveillance, Epidemiology and End Results (SEER) databases between 1992 and 2004. (Source: RWJF News Digest - Public Health)
Response: Don't let the phoney melanoma scare keep you out of the sun
There are many good reasons why we won't ? and shouldn't ? give up our tanKira Cochrane asks "why can't we give up the tan?" (Going for the burn, G2, 7 July). The answer is simple: we are not convinced that the alleged harm outweighs the obvious benefits, and we dislike the bullying, fear-mongering campaign against sun exposure.Skin cancer statistics are used to scare, not educate. Almost all of the 84,000 skin "cancers" that appear each year are in fact benign: they don't spread or kill; their cancerous name is a historical misnomer. Of course, sun exposure increases facial wrinkling, as does smoking, but the black ace in the fear game is melanoma, because the real thing is vicious.As the article tells us, Cancer Research UK say the incidence of malignant melanoma has "quadrupled in B...
Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis
Growth factor receptor (GFR) signaling controls epithelial cell growth by responding to various endogenous or exogenous stimuli and subsequently activating downstream signaling pathways including Stat3, PI3K/Akt/mTOR, MAPK, and c-Src. Environmental chemical toxicants and UVB irradiation cause enhanced and prolonged activation of GFR signaling and downstream pathways that contributes to epithelial cancer development including skin cancer. Recent studies, especially those with tissue-specific transgenic mouse models, have demonstrated that GFRs and their downstream signaling pathways contribute to all three stages of epithelial carcinogenesis by regulating a wide variety of biological functions including proliferation, apoptosis, angiogenesis, cell adhesion, and migration. Inhibiting these s...
Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins
Conclusion:
Altogether, the data show that the receptor tyrosine kinase Xmrk is a useful tool in the identification of target genes that are commonly expressed in Xmrk-transgenic melanocytes and melanoma cell lines. The identified molecules constitute new possible molecular players in melanoma development. Specifically, a role of FOSL1 in melanomagenic processes is demonstrated. These data are the basis for future detailed analyses of the investigated target genes. (Source: BMC Cancer)
Florida?s Minorities See Unusual Melanoma Patterns
Statewide skin cancer rates for blacks, Hispanics differ from U.S. trends (Source: The Doctors Lounge - Dermatology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Melanoma Excision Depth Varies by Physician Specialty
Melanoma specialists who are not dermatologists tend to excise thin invasive melanomas to a deeper
level than do dermatologist specialists and non-specialists, according to research published online July 19 in the
Archives of Dermatology. (Source: Modern Medicine)
Darker skin doesn't mean melanoma immunity
NEW YORK (Reuters Health) - Melanoma is on the rise among certain groups of dark-skinned Floridians, new research shows. (Source: Reuters: Health)
Darker Skin Doesn't Mean Melanoma Immunity
Melanoma is on the rise among certain groups of dark-skinned Floridians, new research shows.Source: Reuters Health
Related MedlinePlus Pages: African-American Health, Hispanic-American Health, Melanoma (Source: MedlinePlus Health News)
Darker skin doesn't mean melanoma immunity
NEW YORK (Reuters Health) - Melanoma is on the rise among certain groups of dark-skinned Floridians, new research shows. (Source: Reuters: Health)
Subsequent Neoplasms in 5-Year Survivors of Childhood Cancer: The Childhood Cancer Survivor Study
Conclusions
As childhood cancer survivors progress through adulthood, risk of subsequent neoplasms increases. Patients surviving Hodgkin lymphoma are at greatest risk. There is no evidence of risk reduction with increasing duration of follow-up. (Source: JNCI)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Archer Biosciences Announces Initiation of Dosing in 3rd Cohort in Metastatic Melanoma Clinical Trial
Archer Biosciences, Inc. announced that the trial of its novel, proprietary drug TPI-287 (an abeotaxane) for the treatment of metastatic melanoma has initiated a third drug-escalation cohort. The primary objective of this study is to determine the safety, tolerability and maximum tolerated dose (MTD) of TPI-287 in combination with temozolomide (TMZ) in adult patients with metastatic melanoma. (Source: Pharmaceutical Online News)
The Prognostic Significance of Nonsentinel Lymph Node Metastasis in Melanoma
Conclusions NSN melanoma metastasis is an independent prognostic factor for DFS and OS, which is distinct from the number of positive
lymph nodes or the lymph node ratio.
Content Type Journal ArticleCategory MelanomasDOI 10.1245/s10434-010-1208-8Authors
Russell E. Brown, University of Louisville, James Graham Brown Cancer Center Division of Surgical Oncology, Department of Surgery Louisville KY USAMerrick I. Ross, University of Texas, MD Anderson Cancer Center Department of Surgical Oncology Houston TX USAMichael J. Edwards, University of Cincinnati College of Medicine Department of Surgery Cincinnati OH USAR. Dirk Noyes, LDS Hospital Department of Surgery Salt Lake City UT USADouglas S. Reintgen, Lakeland Regional Cancer Center Department of Surgery Lakeland FL USAL...
Marjolin?s Ulcers in sub-Saharan Africa
Conclusions Marjolin?s ulcers in sub-Saharan African have a shorter latent period, and they occur in younger patients. Provision of early
stable wound cover is essential for prevention of malignant degeneration of scars, while early appropriate intervention is
crucial in the treatment of chronic ulcers.
Content Type Journal ArticleDOI 10.1007/s00268-010-0727-6Authors
Peter M. Nthumba, AIC Kijabe Hospital Department of Surgery Kijabe 00220 Kenya
Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)
Switch to a Sirolimus-Based Immunosuppression in Long-Term Renal Transplant Recipients: Reduced Rate of (Pre-)Malignancies and Nonmelanoma Skin Cancer in a Prospective, Randomized, Assessor-Blinded, Controlled Clinical Trial
Early studies showed fewer new skin-cancers in patients randomized to sirolimus at the time of transplant. In this single-center trial, patients with a previous non-melanoma skin cancer were randomized to sirolimus or to continue on their current immunosuppression. There was fewer new skin cancers or premalignant lesions in the sirolimus group. This is a small study lasting only twelve months and speaks to the need for larger, longer trials.
:
Increased Incidence of Angioedema with ACE Inhibitors in Combination with mTOR Inhibitors in Kidney Transplant Recipients
Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver Disease
Angiotensin Blockade Is Associated With Early Graft Dysfunction After Live Donor Renal Transplantation (Source: Neph...
TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma
In this study, genetic polymorphisms of TNFRSF1B gene were evaluated Japanese esophageal squamous cell carcinoma (ESCC) patients treated with the definitive 5-FU/CDDP-based chemoradiotherapy and their predictive values of prognosis or severe acute toxicities were assessed.
Methods:
Forty-six patients with ESCC were treated with the definitive 5-FU/CDDP-based chemoradiotherapy, one course of which consisted of the continuous infusion of 5-FU for days 1-5 and 8-12, the infusion of CDDP on days 1 and 8, and the radiation at 2 Gy/day on days 1-5, 8-12, and 15-19, with a second course repeated after 2-week interval. Genetic polymorphisms of a TNF-alpha receptor TNFRSF1B gene were determined by a TaqMan(R) MGB probe-based polymerase chain reaction.
Results:
The genotype of TNFSR1B A1466G, but no...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Increase of ZASC1 gene copy number in recurrent oral carcinoma
Conclusions: The findings support the hypothesis that ZASC1 localized on 3q26 contributes to the recurrence of OSCC. (Source: Oral Diseases)
Melanoma Rate for Black Women, Hispanic Men Higher in Fla.
Hispanic males and non-Hispanic black females residing in Florida have substantially higher incidence
rates of melanoma than those same subgroups residing in the United States as a whole, according to research
published in the July issue of the Archives of Dermatology (Source: Modern Medicine)
Immunologic Response to Xenogeneic gp100 DNA in Melanoma Patients: Comparison of Particle-Mediated Epidermal Delivery with Intramuscular Injection.
CONCLUSION: A comparable efficacy and safety profile was shown between the i.m. and PMED arms, despite a significantly decreased dose of DNA used for PMED injection. Clin Cancer Res; 16(15); 4057-65. (c)2010 AACR.
PMID: 20647477 [PubMed - as supplied by publisher] (Source: Cell Research)
Conditional Survival Among Cancer Patients in the United States.
Conclusion. Conditional survival probability estimation provides further useful prognostic information to cancer patients, tailored to the time already survived since diagnosis.
PMID: 20647391 [PubMed - as supplied by publisher] (Source: The Oncologist)
Can diffusion-weighted imaging distinguish between normal and squamous cell carcinoma of the palatine tonsil: a preliminary study.
Authors: Bhatia KS, King AD, Yeung DK, Mo F, Vlantis AC, Yu KH, Wong JK, Ahuja AT
The utility of diffusion-weighted imaging (DWI) in the detection of squamous cell carcinoma (SCC) of the tonsils has not been previously investigated. This preliminary study compared DWI of apparent SCC tonsillar tumours with normal tonsils. DWI of the tonsils was performed in 10 patients with newly diagnosed tonsil SCC that was evident on conventional MRI and in 17 patients undergoing cranial MRI for other indications. Regions-of-interest (ROI) were drawn around each identifiable tonsil on the apparent diffusion coefficient (ADC) map and the mean ADC value for each tonsil was calculated. ADC values for normal and SCC tonsils were compared using the Mann-Whitney U-test. The median ADC and range (x10(-3) m...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Down-regulation of survivin by oxaliplatin diminishes radioresistance of head and neck squamous carcinoma cells
Conclusions: Higher expression of survivin is a critical factor for radioresistance in HNSCC cell lines. Pre-treatment of cancer cells with oxaliplatin significantly increased the radiosensitivity through induction of apoptosis by potently inhibiting survivin. (Source: Radiotherapy and Oncology)
Ethnic Differences Seen in Melanoma in Florida (CME/CE)
Melanoma incidence among some nonwhites in Florida differs from other parts of the country (MedPage Today) -- suggesting new public health concerns in an area with high ultraviolet light exposure, according to a new study. (Source: MedPage Today State Required CME)
Mbeach Software Inc. Targeting Growing Market for Non-Intrusive Technologies to Detect Skin Cancer
TEL AVIV, Israel, July 19, 2010 (GLOBE NEWSWIRE) -- Mbeach Software Inc. ("MBHS") (OTCBB:MBHS) today issued a stockholder update on the growing market for skin cancer diagnostic solutions. These market developments represent significant opportunities for the wholly owned subsidiary, Skin Cancer Scanning Ltd. ("SCS") to grow the company and become a leading industry player. (Source: Medical News (via PRIMEZONE))
Skin Cancer Awareness, Attitude, and Sun Protection Behavior Among Medical Students at the University of Miami Miller School of Medicine [Research Letters]
(Source: Archives of Dermatology)
Durable Complete Remission of Therapy-Refractory, Tumor-Stage Cutaneous T-Cell Lymphoma Under Radioimmunotherapy With Electron Beam Irradiation and Denileukin Diftitox [Correspondence]
(Source: Archives of Dermatology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Increasing Rates of Melanoma Among Nonwhites in Florida Compared With the United States [Study]
Conclusion These findings suggest an emerging public health concern in race/ethnic subgroups that were previously understudied. (Source: Archives of Dermatology)
Focally Pigmented Pink Plaque on the Back--Quiz Case [Off-Center Fold]
(Source: Archives of Dermatology)
Focally Pigmented Pink Plaque on the Back--Diagnosis [Off-Center Fold]
(Source: Archives of Dermatology)
Desmoplastic Melanoma in African American Patients [Research Letters]
(Source: Archives of Dermatology)
Squamous Cell Carcinoma of the Oral Tongue in the Pediatric Age Group: A Matched-Pair Analysis of Survival [Original Article]
Conclusions When pediatric and adult patients were matched for sex, tobacco use history, TNM status, surgical procedure, and adjuvant radiotherapy, outcomes for OS, DSS, and RFS were equivalent. Pediatric patients with SCC of the oral tongue should be treated similarly to adult patients. (Source: Archives of Otolaryngology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Prognostic Information From Sentinel Lymph Node Biopsy in Patients With Thick Melanoma [Paper]
Conclusion The SLN biopsy provides useful prognostic information for patients with T4 melanoma. (Source: Archives of Surgery)
Variation in the Depth of Excision of Melanoma: A Survey of US Physicians [Study]
Conclusions There is considerable variation among physician groups with regard to depth of excision practices for the treatment of melanoma. Given the current lack of clinical data available, studies assessing depth of excision and patient outcomes are needed to better define our surgical management of melanoma.Published online July 19, 2010 (doi:10.1001/archdermatol.2010.156). (Source: Archives of Dermatology)
Orbital and myocardial metastases of a primary pulmonary melanotic schwannoma
We present the case of a 60-year-old man with a primary pulmonary melanotic schwannoma treated with surgery and who developed
an orbital and myocardial relapse 2 years after the initial diagnosis. Melanotic schwannomas are rare pigmented tumours that
tend to arise from the peripheral nerves near the midline. A primary lung presentation, as in our case, is extremely rare.
In more than half of cases, the Carney triad of myxomas of the heart, skin and breast, spotty pigmentation and endocrine hyperactivity
is present. A thorough pathological study is pivotal for a correct diagnosis. The main differential diagnosis is with metastases
of malignant melanoma. The biological behaviour is unpredictable. Treatment should include radical surgery if possible; the
role of chemotherapy and radioth...
Melanoma rates among minorities in Florida differ from national trends
(JAMA and Archives Journals) Racial and ethnic trends in the skin cancer melanoma appear different in Florida than from national estimates, with higher incidence rates among Hispanic men and nonHispanic black women but lower rates among Hispanic women, according to a report in the July issue of Archives of Dermatology, one of the JAMA/Archives journals. (Source: EurekAlert! - Cancer)
Serum IL10 and circulating CD4+CD25high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma
Patients with head and neck squamous cell carcinoma (HNSCC) commonly have an imbalance in T helper (Th)1/Th2-type cytokines and elevated levels of CD4+CD25high regulatory T cells (Treg). Here, we investigated the association of circulating interleukin (IL)10, IL12, and Treg-cells with clinical outcome in patients with HNSCC.Serum cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA) in patients' pretreatment (n = 107) and 4 to 6 weeks posttreatment (n = 43), and in nontumor controls (n = 40). Treg-cell levels were determined by flow cytometry.IL10 detectability was significantly higher in patients than controls (p = .001). Pretreatment IL10 levels in all anatomical subsites, except the oral cavity, were significantly elevated in stages III/IV, N+ patients, and in T3/...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically-important and correspond to different normal cell types.
CONCLUSIONS: Lung SCC consists of four mRNA expression subtypes that have different survival outcomes, patient populations, and biological processes. The subtypes stratify patients for more precise prognosis and targeted research.
PMID: 20643781 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Ophthalmomyiasis: Three cases from North India
S Khurana, M Biswal, HS Bhatti, SS Pandav, A Gupta, SS Chatterjee, WV Lyngdoh, N MallaIndian Journal of Medical Microbiology 2010 28(3):257-261Three cases of external ophthalmomyiasis are reported here. The larvae were identified to be Oestrus ovis in two cases and Cochliomyia hominivorax in one. Two of the patients were immunocompetent while one was undergoing treatment for squamous cell carcinoma of eyelid. In the latter myiasis led to complete destruction of the eye. (Source: Indian Journal of Medical Microbiology)
Comparison between two methods for human papilomavírus DNA detection in lip squamous cell carcinoma
Conclusion: HPV DNA detection of lip SCC increased sixfold in the studied cases with the employment of nPCR. (Source: Jornal Brasileiro de Patologia e Medicina Laboratorial)
Immunohistochemical assessment of E-cadherin, β-catenin, CEACAM-1 and PTEN: tumor progression markers in melanoma
CONCLUSION: There was a higher positivity for E-cadherin, b-catenin and PTEN in thin melanomas, whereas there was a higher positivity for CEACAM-1 in thick melanomas.INTRODUÇÃO E OBJETIVO: O objetivo do presente estudo está na avaliação imuno-histoquímica de marcadores de progressão tumoral (E-caderina, ?-catenina, CEACAM-1 e PTEN) em melanomas cutâneos primários e sua correlação com fatores prognósticos. MÉTODO: Lesões primárias de pacientes portadores de melanoma cutâneo foram tabuladas quanto a dados clínicos (idade, sexo, localização e metástases) e anatomopatológicos (Breslow, nível de Clark, margens, tipo histológico, mitoses, ulceração, regressão, satelitose e tipo de TIL). Foi realizada comparação da expressão imuno-histoquímica dos marcadores em estu...
Epithelial trophoblastic tumor associated with in situ squamous cell carcinoma of the cervix
Epithelioid trophoblastic tumors are rare neoplasias that develop from the neoplastic transformation of chorionic-type intermediate trophoblasts. They show a wide spectrum of differential diagnoses. The authors describe a case of epithelioid trophoblastic tumor with atypical presentation in a 26-year-old patient that had recently undergone conization for in situ squamous cell carcinoma of the uterine cervix. The histopathology, immunohistochemistry and differential diagnoses of the lesion are also discussed. No similar case had been reported in the medical literature and it is an example of the hindrances to the diagnosis of epithelioid trophoblastic tumors.Os tumores trofoblásticos epitelioides são neoplasias raras que se desenvolvem a partir da transformação neoplásica de trofoblast...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Small cell variant of squamous cell carcinoma vs. small cell carcinoma of the lung: differential diagnosis in biopsies
O diagnóstico diferencial entre a variante pequenas células do carcinoma epidermoide e do carcinoma de pequenas células nem sempre é fácil. Apesar de os descritores alertarem que o primeiro deva manter suas características morfológicas e, muitas vezes, diferenciação escamosa focal, a escassez de material aliada a artefatos de fixação frequentes nessas biópsias podem dificultar a vida do patologista. Entretanto, a definição entre um e outro pode alterar significativamente a escolha da modalidade terapêutica do paciente e, em alguns casos, influenciar seu prognóstico. Procuramos nesta publicação alertar para o problema e facilitar essa diferenciação, sugerindo um painel imuno-histoquímico.The differential diagnosis between small cell variant of squamous carcinoma and sma...
Up-regulation of histidine decarboxylase expression and histamine content in B16F10 murine melanoma cells
Conclusion Results indicate an up-regulated histaminergic system in the B16F10 melanoma cells when compared to non-cancerous melanocytes.
This supports the use of B16F10 cells as a model in which to investigate a potential role of the endogenous histaminergic
system in regulating malignant cell function.
Content Type Journal ArticleCategory Original Research PaperDOI 10.1007/s00011-010-0234-0Authors
Steven C. Davis, Joan C. Edwards School of Medicine, Marshall University Department of Pharmacology Huntington WV 25704-9388 USASheena Clark, Joan C. Edwards School of Medicine, Marshall University Department of Pharmacology Huntington WV 25704-9388 USAJ. Robert Hayes, Joan C. Edwards School of Medicine, Marshall University Department of Pharmacology Huntington WV 25704-...
Association of Choline Levels and Tumor Perfusion in Brain Metastases Assessed with Proton MR Spectroscopy and Dynamic Susceptibility Contrast-enhanced Perfusion Weighted MRI.
Authors: Huang BY, Kwock L, Castillo M, Smith JK
While malignant brain tumors typically show high choline concentrations and neovascularity, we have anecdotally noted that a substantial number of brain metastases from lung cancer demonstrate only mildly elevated choline resonances on proton MR spectroscopy ((1)H-MRS). The goals of this study were to determine whether lung cancer metastases are more likely to demonstrate low choline than other metastases and, in addition, to assess the relationship between choline and tissue perfusion in brain metastases. We performed a retrospective analysis of 66 patients with untreated brain metastases (40 NSCLC; 17 breast cancer; 9 melanoma) who underwent multivoxel 2D-CSI (1)H-MRS. Cho/Cr was compared between histologies using Mann-Whitney U tests....
Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma
We describe here a rare case of the transformation of a supratentorial melanocytoma and diffuse melanocytosis into a primary
malignant, CNS melanoma. A 71-year-old woman was admitted after suffering from bulbar speech and dysfunction of fine motor
skills for three years. Cerebral imaging revealed an inhomogeneous tumor mass in the right frontal lobe. After craniotomy
and opening of the dura, a partially black brain surface was exposed. The solid tumor mass was completely resected. Histopathological
workup of the surgical specimen (solid tumor) revealed a melanocytoma with transformation into a malignant melanoma. Three
months after surgery, an MR scan was carried out, revealing local tumor recurrence and intracranial spreading. At this time
the patient agreed to undergo whole brain r...
Improved melanoma survival at last! Ipilimumab and a paradigm shift for immunotherapy
(Source: Pigment Cell Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Immunosuppressive treatment after solid organ transplantation and risk of post-transplant cutaneous squamous cell carcinoma
Conclusions. This study provides evidence that Aza treatment, but not cyclosporine treatment, is strongly associated with post-transplant CSCC risk. The results suggest that the risk of CSCC after organ transplantation is not only an effect of the immunosuppressive load per se. (Source: Nephrology Dialysis Transplantation)
Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits tumor metastasis in mouse melanoma through suppression of the Rho/ROCK pathway
In this study, we investigated whether YM529/ONO-5920 inhibits tumor cell migration, invasion, adhesion, and metastasis
in B16BL6 cells, a mouse melanoma cell line. It was found that YM529/ONO-5920 significantly inhibited lung metastasis, cell
migration, invasion, and adhesion at concentrations that did not show anti-proliferative effects on B16BL6 cells. YM529/ONO-5920
also inhibited the expression of matrix metalloproteinases (MMPs) and very late antigens (VLAs). Furthermore, YM529/ONO-5920
suppressed Rho activation, but not activation of Ras. The results indicate that YM529/ONO-5920 suppresses the Rho/ROCK pathways,
thereby inhibiting B16BL6 cell migration, invasion, adhesion and metastasis. These findings suggest that YM529/ONO-5920 has
potential clinical applications for the tre...
High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma
Conclusion Our results suggest that an increased MDA level at the time of initial surgery is found in patients with a high risk of recurrence,
which suggests that each patient can be categorized according to risk of recurrence based on their MDA level at the time of
initial surgery.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0108-zAuthors
Richard Salzman, St. Anne?s Faculty Hospital Department of Otorhinolaryngology and Head and Neck Surgery Peka?ská 53 656 91 Brno Czech RepublicLuká? Pácal, Masaryk University Department of Pathophysiology, Faculty of Medicine Komenského nám. 2 662 43 Brno Czech RepublicKate?ina Ka?ková, Masaryk University Department of Pathophysiology, Faculty of Medicine Komenského nám. 2 662 43 Brno ...
Applications of diffusion-weighted magnetic resonance imaging in head and neck squamous cell carcinoma
Abstract In the head and neck, squamous cell carcinoma is one of the most common tumour types. Currently, the primary imaging modalities
for initial locoregional staging are computed tomography and?to a lesser extent?magnetic resonance imaging, whilst [18F]fluorodeoxyglucose (FDG) positron emission tomography has additional value in the detection of subcentimetric metastatic
lymph nodes and of tumour recurrence after chemoradiotherapy (CRT). However, dependency on the morphological and size-related
criteria of anatomical imaging and the limited spatial resolution and FDG avidity of inflammation in metabolic imaging may
reduce diagnostic accuracy in the head and neck. Diffusion-weighted magnetic resonance imaging (DWI) is a noninvasive imaging
technique that measures the...
Hyaluronan Stabilizes Focal Adhesions, Filopodia, and the Proliferative Phenotype in Esophageal Squamous Carcinoma Cells [Glycobiology and Extracellular Matrices]
In conclusion, HA synthesis and, in turn, RHAMM and CD44 signaling promoted an activated phenotype of OSC1. Because RHAMM appears to support both filopodia, FAK, and the proliferative and migratory phenotype, it may be promising to explore RHAMM as a potential therapeutic target in esophageal cancer. (Source: Journal of Biological Chemistry)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Fredericksburg Oncology Announces New Melanoma Clinical Trial Now Open
Fredericksburg Oncology is now accepting patients for a new clinical trial supported by the National Cancer Institute (NCI) to evaluate treatment for metastatic (advanced stage) melanoma. The current trial, designed at the Mayo Clinic, combines chemotherapy with targeted molecular agents in an effort to improve control of this difficult disease, reports Dr. Frederick C. Tucker, Jr., who heads this practice. "When discovered early, Melanoma is a curable skin cancer. However, when skin cancer spreads to other organs in the body it has proved very difficult to treat," said Dr... (Source: Health News from Medical News Today)
Alpha B-Crystallin: An Independent Marker For Prognosis In Lung Cancer?
Background: Alpha B-Crystallin (CRYAB) is a molecular chaperone of seemingly diverse function. CRYAB is an independent prognostic marker in head and neck squamous cell carcinoma (HNSCC) and breast cancer , associated with poor outcome. There is evidence for the role of CRYAB as an oncogene and previous descriptions of its role in increasing tumour survival by promoting angiogenesis and prevention of apoptosis . Alpha B-Crystallin has previously been associated with other tumours including glioma, rectal and thyroid carcinomas, as well as degenerative and demyelinating neurological disease, and it has been shown that CRYAB is overexpressed in stressed tissues as in ischaemic heart disease. (Source: Heart, Lung and Circulation)
Differential expression of intracellular innate immune cytosolic pathogen sensing receptors in the human female reproductive tract
NOD1, NOD2 (nucleotide binding oligomerization domain), RIG1 (retinoic acid inducible gene) and MDA5 (melanoma differentiation associated gene) comprise an intracellular pathogen sensing pattern recognition receptor (PRR) system. The NOD proteins recognize bacterial pathogens whereas the RIG1 and MDA5 recognize viral. Our study was aimed at determining the expression and induction patterns of all four PRR by epithelial cells from the female reproductive tract (FRT). We also determined the effects of estradiol and Neisseria gonorrhea, an intracellular FRT pathogen, on PRR expression. Epithelial cells (Ec) were isolated from Fallopian tube (FT), endometrium (EM), cervix (Cx) and ectocervix (Ecx) from hysterectomy patients by enzymatic digestion. Cells were treated with estradiol, Poly(I:C) (...
Cutaneous Metastasis of Squamous Cell Carcinoma of Oral Mucosa with a Purpura-Like Appearance with Tumor Thrombosis in Lymphatic Vessels
The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)
Micrographic surgery of skin cancer in German hospitals 2005–2006
Conclusions Micrographic surgery is frequently used for the local treatment of NMSC and varies considerably across Federal States of Germany. It is difficult to speculate how many MS might be performed in private or ambulatory settings in Germany. As MS requires surgical expertise, technical support and dermatopathology, we speculate that MS is much less frequently undertaken in private practices in Germany. (Source: Journal of the European Academy of Dermatology and Venereology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Ovarian malignant melanoma without evidence of teratoma
A 46-year-old woman with ovarian malignant melanoma had advanced intraperitoneal metastasis, retroperitoneal and inguinal lymph node metastases. Extensive debulking surgery was performed and chemotherapy was given. Microscopically, no evidence of other accompanying tumor, such as teratoma was noted. Detailed examination of the patient failed to identify any evidence of another primary melanoma site. It is assumed that spontaneous regression of the primary lesion occurred. Despite the surgery and chemotherapy, the patient died within 2 months of diagnosis. Considering this case, it is assumed that the combination of surgical debulking and chemotherapy are not always beneficial in ovarian malignant melanoma and the prognosis of ovarian malignant melanoma is very poor. (Source: Journal of Obs...
[Editorial] Lighting the way to better health: vitamin D
The public health message is compellingly simple: avoid the sun to prevent melanoma and other forms of skin cancer. Unfortunately, exposure to sunlight is the mainstay of vitamin D synthesis, and vitamin D deficiency causes rickets and osteomalacia, contributes to osteoporosis, and has been associated with many other disorders, including diabetes, cancer, and cardiovascular disease. (Source: LANCET)
[Correspondence] The questionable effectiveness of sunscreen
In their Seminar (Feb 20, p 673), Vishal Madan and colleagues highlight a rising incidence of non-melanoma skin cancer (NMSC) in several countries. The incidence of NMSC also seems to be increasing in the USA. This increase is the reverse of what is expected given the continued increased purchase of sunscreen per head in the USA and UK since the 1990s (). (Source: LANCET)
[Correspondence] The questionable effectiveness of sunscreen ? Authors' reply
We agree with Adam Handel and Sreeram Ramagopalan that, despite increased population exposure to sunscreens, the risk of melanoma and non-melanoma skin cancers (NMSC) is on the rise. The suggestion that increased population exposure to sunscreen does not translate into a reduced risk of skin cancers is, however, not entirely true. Although sunscreen use has not been shown to offer protection from melanoma and basal-cell carcinomas, there is ample evidence to support the protective effects of consistent application of sunscreens against squamous-cell carcinomas and precursor lesions, even in immune-compromised recipients of organ transplants. (Source: LANCET)
Down-regulation of survivin by oxaliplatin diminishes radioresistance of head and neck squamous carcinoma cells.
CONCLUSIONS: Higher expression of survivin is a critical factor for radioresistance in HNSCC cell lines. Pre-treatment of cancer cells with oxaliplatin significantly increased the radiosensitivity through induction of apoptosis by potently inhibiting survivin.
PMID: 20638740 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Glycoprotein capture and quantitative phosphoproteomics indicate coordinated regulation of cell migration upon lysophosphatidic acid stimulation.
In conclusion, the glycoproteome phosphoproteomics strategy described here sheds light on incompletely understood mechanisms in LPA-induced cell migratory behavior.
PMID: 20639409 [PubMed - as supplied by publisher] (Source: Molecular and Cellular Proteomics : MCP)
mBeach Software Inc. Finalizes Acquisition of Skin Cancer Scanning Ltd.
TEL AVIV, Israel, July 15, 2010 (GLOBE NEWSWIRE) -- mBeach Software Inc. ("MBHS") (OTCBB:MBHS) announced today that it has finalized and closed the merger for the acquisition of Skin Cancer Scanning Ltd. ("SCS"). As a result of the acquisition, MBHS will hold 100% of SCS. (Source: Medical News (via PRIMEZONE))
Provectus Pharmaceuticals Reports Achieved Milestones for First Half of 2010, Recent Developments and Plans for the Remainder of the Year to Shareholders
KNOXVILLE, Tenn.--(HSMN NewsFeed)--Provectus Pharmaceuticals, Inc. (OTC BB: PVCT) reports on its first half 2010 clinical and corporate accomplishments, as well as its clinical development plans, in a letter to shareholders from Craig Dees, Ph.D., CEO of P... Biopharmaceuticals, Dermatology, OncologyProvectus Pharmaceuticals, psoriasis, metastatic melanoma (Source: HSMN NewsFeed)
Processing and cross-presentation of individual HLA-A, -B, or -C epitopes from NY-ESO-1 or an HLA-A epitope for Melan-A differ according to the mode of antigen delivery
The ability of dendritic cells (DCs) to cross-present protein tumor antigens to cytotoxic T lymphocytes (CTLs) underpins the success of therapeutic cancer vaccines. We studied cross-presentation of the cancer/testis antigen, NY-ESO-1, and the melanoma differentiation antigen, Melan-A by human DC subsets. Monocyte-derived DCs (MoDCs) efficiently cross-presented human leukocyte associated (HLA)–A2-restricted epitopes from either a formulated NY-ESO-1/ISCOMATRIX vaccine or when either antigen was mixed with ISCOMATRIX adjuvant. HLA-A2 epitope generation required endosomal acidification and was proteasome-independent for NY-ESO-1 and proteasome-dependent for Melan-A. Both MoDCs and CD1c+ blood DCs cross-presented NY-ESO-1–specific HLA-A2157-165–, HLA-B760-72–, and HLA-C...
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